Nutramax Denamarin for Medium Dogs, Liver Health Supplement with S-adenosylmethionine (SAMe) plus Silybin, Liver Support for Dogs, Coated Tablets, 30 Count

I foster dogs, but have chosen to specialize in the older and sicker rescued dogs. I have had many, many dogs with liver problems. But for a long time we were losing our precious furry friends, it was awful, there just was not really a very good treatment out there for an old dog with bad liver readings. The problem was that the old dogs all had arthritis, many had been brutalized and abandoned by previous owners, and there were some things that could not be fixed. However, finally we had access to a wide canine assortment of NSAID's. This was wonderful, the previous only hope was aspirin, with many associated bleeding risks, or dangerous steroids for their poor inflamed, badly healed, and otherwise painful limbs. They were always so good, even though I knew that they were suffering. Then, we suddenly had access to the wonderful mom-steroidal pain relievers. This was magic stuff. Dogs that could barely walk were bouncing around, dogs that could not climb stairs were bounding up, two steps at a time. However, there was a dark side to all of this joy...as we soon discovered. These miracle NSAID's were pretty rough on the livers of the old dogs. So much so that I was faced with the awful choice of continuing that medication, knowing that it was destroying their liver, but it was also keeping the dogs joints pain-free. My other alternative was no good alternative - no NSAIDS, just heavier and heavier doses of narcotics for the pain......helplessly watching the failing test results of my poor old pups. I lost quite a few that way, it almost killed me. Then Denamarin, and Marin came along. I use both on my old pups and it is another miraculous thing to witness. This is a nom-prescription item that magically lowered bad liver numbers, sometimes within a three or four week period.. It is very expensive, but Amazon has the best price of all. My dogs are living now, and not teetering on the edge with failing livers. It is possible to use NSAID's in conjunction with Denemarin, and the liver numbers are far better, and the dogs are not doped-up on narcotics, but can enjoy their last days. I am amazed by the breakthroughs that I have witnessed in the veterinary world over the last ten years that I have been fostering. Sometimes it is pretty magical, old dogs frolicking around my ankles each morning, demanding a treat, just like a bunch of pups. I am not a vet., I wish to make that crystal clea. I have no connection whatsoever with this company, indeed had never heard of them before my vet mentioned this drug. All that I can say is that I have had dogs my entire life, and I have witnessed far too many agonizing decisions that have had to be made. Watching an agonized old dog, painfully hobble around, or give the drug that will help with the arthritis...and have very negative effects with their livers. In the.end, we usually just tried to keep them out of pain, but they had.no good quality of life. Again, to be perfectly clear, with MY old dogs, under MY care, eating the very best of dog kibble, no fatty treats, no people food, and someone around at all times to give the drugs at the appropriate times, I have seen rapidly discernible improvement in my older guys. Not every dog reacts the same way, doses can be tricky, and.require a lot of blood testing' and fiddling with dosages, my dogs have definitely improved. Not all have a glorious outcome. But If they are willing to get out of their beds, and follow me to the kitchen to beg for food, my heart is happy. When you are working with old, injured, and sick dogs...little things matter a lot. Denemarin, along with another supplement : Marin, have made the lives of some of the older fur kids better, and happier. This will not save your old dog, there will be heart problems, cancers, and other issues upon which Denemarin has no effect. But for the dogs in the specific conditions that I have outlined, I have seen a definite difference in both the quality of life for the dog, as well as better liver readings on their blood tests. Again, it is expensive, this makes for a very hard decision for every pet lover. But, it is effective on many dogs. And that is a miracle for me. We are saving dogs that we would have lost ten years ago, and this supplement has had a lot to do with that. It is up to the pet owner, but under the conditions that I have stipulated, this is a worthwhile addition to the supplemental diet of old dogs.

I have 2 cats which I adopted in 2010 that spent the first 3.5 years of their life with chronic diarrhea, on and off metronidazole during that time, only for the diarrhea to return shortly after the antibiotic was stopped. Stools were always negative, but I found out my one cat had sky-high liver enzymes. I tried this (one pill for each cat at bedtime) and they had perfect poop within about 2 days. Also, my cat's liver enzymes quickly returned to normal. I treated the cat with the high liver enzymes for about 3 months and stopped. Both cats still had perfect poop, but the cat who had the sky-high liver enzymes in the past (at some point) started hiding under a comforter on the chair all day (which was not like him), and when I'd peek under I could just tell he wasn't feeling well. I didn't take him to the vet because he'd always act perky at mealtime. (In retrospect, I believe he started hiding around the time I stopped the Denamarin.) Fast forward to now, 2016... My husband & I started giving them bits of table food because we couldn't resist their begging - perhaps the trigger? Both cats developed diarrhea again and were treated by a new vet with metronidazole & amoxicillin (both positive for clostridium). Looking back in their records, they were positive for this in the past, but vets only ever treated them with metronidazole and never mentioned anything about clostridium to me. I was hopeful that clostridium had been been the cause all along and that these 2 antibiotics together would finally rid them of diarrhea forever, but even after a round of this combination, they still had stools the consistency of pudding. When I asked for another round of antibiotics, the vet refused and told me to take them both to a specialist and recommended (VERY expensive) endoscopies. I had already spent so much money in the past on stool tests, even a comprehensive and expensive stool test, probiotics, digestive enzymes, various cat foods, etc... Nothing ever helped. So I decided to start them both on Denamarin again - one pill at bedtime for each - and their stools were perfect again within 2 days. This stuff is nothing short of a MIRACLE for cats with CHRONIC DIARRHEA. I've therefore decided I will be giving them this f-o-r-e-v-e-r, and of course, resist giving them any table food. :-/ +++++ UPDATE (November 2017)...additional information... This is nothing short of a miracle for acute and chronic diarrhea in cats. I have two cats who had acute and chronic diarrhea from the day I brought them home from a shelter as kittens. THREE & A HALF YEARS of stool testing, even an expensive 'comprehensive stool panel' on the one who always got the sickest, all negative except a toxin present for clostridium perfringens, which the vet blew off as 'harmless' and not the cause. Both cats would always be prescribed a course of Metronidazole, so I knew a 'bug' was involved. Metronidazole would help firm them up some in the sickest cat, completely in the other cat, but then back to the mashed potato poop and squirts in no time. Whether or not it was this 'harmless' bacteria or not, I have no idea. I was told it must be 'food allergies', but tried every limited ingredient canned cat food I could find to no avail. And BOTH cats supposedly had food allergies even after stopping the tidbits of table food? My one cat, when tested, had high liver enzymes, 5 times higher than normal. I spent many nights googling how to bring his liver enzymes down. That is how I first came across Denamarin. He honestly looked like he was dying. ONE PILL and within the next day or two he had his FIRST normal bowel movement in his LIFE. I can't believe he had to live the first 3 1/2 years of his life sick like this. He was the one who would always get the sickest, but eventually if one had diarrhea, the other one would get it too. I will give him one pill for the rest of his life because when I stop, within a couple of months he'll start look sickly and eventually have an acute bout of diarrhea, turning chronic, the other cat contracting it soon after. During the time period I had stopped giving this one cat Denamarin, he developed one of these horrible bouts of diarrhea (the other cat soon after). He wouldn't eat, would pace and pant until he threw up to the point of dehydration, and would run to the litter box with the squirts, runs, mushy poop. Took him to an emergency veterinary hospital, and all they gave him was an anti-nausea medication, something to calm his stomach, and sub-q fluids. Next day he had diarrhea still. I called the hospital, and this vet refused to prescribe Metronidazole even though I'd just paid $530. So I pulled out the Denamarin...diarrhea gone the next day. Just last night I noticed the other cat had formed, but soft stool, mushy at the very end. I panicked and gave him a Denamarin. He didn't poop at all today. Denamarin is a MIRACLE, and if you have a cat in this situation...chronic or acute diarrhea, routine stool tests negative or comprehensive stool panels positive for ANY so-called 'harmless' bacteria or bacterial toxin, this is worth a try. Seriously, I love this stuff so much, I could do a commercial for it. I'm posting this, not because I'm positive it will help every cat, but I plead with anyone in similar situations to give this a try. I am convinced this pill saved my one cat's life. I give it to him daily, and I watch the stools of my other cat and may even start giving it to him daily as a precaution.

I have ordered this for the second time. It was recommended by the Vet for my 17 year old Corgi for his liver. Now he is back to his old feisty self, making re energy, and definitely better breath. This has really helped his health.

It's a great product. It works very well but my dog got to where he wouldn't take it. No more. He wasn't feeling well and he's not doing very well so I wasn't forcing it on him. But the product is really good. There's nothing wrong with the product

Gave this to my cat based on my vet's recommendation, because she had high liver values. After a month they did go down, we're not sure if it's due the denamarin or other treatments, but she's going to stay on it. My cat HATES taking pills, and a downside is these pills are rather large. Like a human ibuprofen sized pill. They can't be cut or crushed, and honestly I tried it and it smells so bad that she would not take it that way anyway. If crushed or cut and it gets wet it smells like burnt rubber. I also tried rubbing butter around it, reading somewhere that the fat will help it not get the moisture issue. But that didn't work well either. In case it helps, what finally got her to start taking, it was using a pill paste I found on Amazon and wrapping around the pill. My cat does not like pill pockets, I tried every brand and flavor and she did not like that. But there's a bacon flavored pill wrap that's like a putty that she'll tolerate. I take that and fold it in some bonito flakes (basically the pill wrap helps the bonito flakes stick). So it's not on a empty stomach, but it's the only way that she'll actually eat the pill. If she tastes the pill at all she not only won't swallow it, and if she does swallow but somehow gets a taste of it, she will throw it up. But she loves bonito flakes so much and she eats them so fast that she swallows the pill whole. It's been over 2 months and it's still working every night, thank goodness.

This is great liver support for my older small dog. She had heightened liver enzyme and very swollen abdomen. She is like a puppy again, after taking this, seriously. Well worth it. Thank you Nutramax!

Vetri-Liver and Denamarin is working!!! My story: Our dog is a 12ish Jack Russell mix. In August 2017, he was off. Not himself. Bloodwork and ultrasound showed he likely had Chronic Hepatitis. Put him on Denamarin. Bloodwork improved, but still not perfect. Had the vet do a dental thinking that the liver issues could be from bad teeth. They put him on a preventative antibiotic. 1 week after the Dental he spiked a 106 fever. He was ultimately put on IVs with a different antibiotic. Fever came down, felt better. Noticed that he had developed a licking issue after eating which was new. Fever slowly started to climb back upward. At 104 he was put back on IVs, taken off of all antibiotics in an attempt to get the bacteria to flourish and to isolate it. The only problem was that once he was off of the antibiotics his temperature went normal never to return. Eating throughout this has been difficult. Turning down filet mignon or whatever concoction I could come up with to tempt him to eat. I had pointed out to the vets (lots of them) that the antibiotics warned against liver and kidney issues. Everyone poo poo'd that. Well, it turns out that his liver couldn't process them. I took him home on Christmas Day from the vet hospital. They wanted to do a liver biopsy, but I rejected it. He already looked like warmed over death. Wasn't eating a thing in the hospital. They would have had to put him back on antibiotics. - And there was no clear indication that the liver was the origin of the problem, and could just be a secondary to another issue like heart disease (he does have a small heart murmur, but his heart is working sufficiently), cancer, etc. Even if we knew exactly what the liver diagnosis was, the treatment wouldn't be much different: Diet, supplements and potentially prednisone (which is hard on the liver as well - catch 22) At home, he was a new dog. He started eating. I researched every liver diet, and started with a very bland, home-cooked meal. I noticed that if I added a hi-end kibble to his diet, there would be more licking (licking surfaces like the carpeting). I read where compulsive licking is often intestinal distress. I'm not convinced that he also didn't have some kind of gastric issue, like gastric ulcers, or other intestinal issue, perhaps because of the liver or maybe even driving the liver problem. It is the end of April 2018, and he is doing well. I started him on Vetri-liver in the AM a couple of months ago with a breakfast of eggs, cottage cheese, oatmeal, rice, and chicken/turkey or beef). The Vetri-liver isn't extremely palatable, but I just cut it in pieces and put it in meat or cheese, and it will go down. Since I don't have a firm diagnosis for the liver problem, I looked for zinc and anti-oxidants to help the liver even if he had a copper retention problem. Zinc is supposed to offset copper in your diet. It also has some other supplements that he may need. Afternoon, he gets his Denamarin tablet (2 hours after the last meal) and 1 hour before dinner. Supposedly vegetable protein is better for dogs with liver disease. So I came up with some treats that also helped, especially in the beginning when getting him to eat was hard. I fill a turkey pan with: eggs, meat, carrots, sweet potatoes, tofu, wheat germ, peanut butter, coconut oil, and enough oats and a little bit of flour to make a cookie dough. The secret ingredient is a little bacon grease and bacon for palatability. Yes, bad, but makes the difference between this going down the hatch. These can be a mid-day snack, or actually a small meal if we are out hiking, etc. I bake them on cookie tins like brownies, cut them into squares, put them in baggies, and throw them in the freezer. This way they stay fresh. Dinner is rice/oatmeal/sweet potatoes/pumpkin or yams mixed with eggs/chicken/turkey/beef along with some well-processed veggies. I'm not convinced that I'm feeding a balanced diet, so I bought some senior dog vitamins that he gets periodically. Slowly the weight is coming back on. Exercise is important, because he is hungry after exercise. So a small walk in the morning before breakfast and walk before dinner really makes a difference with the pills and food going down. As long as he is eating soft, smaller meals, the compulsive licking has stopped. He is energetic, playing with toys, bright on his walks and back among the living. His liver enzymes are not perfect: ALT started at 275 (August 2017), went to 1,800 during the antibiotic reaction and spiked fever, back to 275 and now down to 253 most recently. ALP started at 263, 656 at its worst, and now at 167. I don't know if I will be successful in getting them to normal ranges, but if I look at his quality of life, it looks pretty good now. I wanted to share my story, because you don't hear often that antibiotics could almost kill your dog. And.....your dog can come back after refusing to eat anything after dire illness. Considering a backpack Trip!!

Over two years ago my dog (then three years old) was going into renal failure. I lost a dog to it before, (senior foster dog with unknown past) but none of the same factors were at play here. I was so scared because I was so helpless before. Milk thistle was mentioned this time, I did the reading on it, & due to my dog's plant allergies I decided to give this a try. It is expensive, but WELL worth it. With in a couple weeks her values were back in normal range. We kept her on it daily for over a year. For about a year now we've given it to her about every other day & she is still doing great in regards to her liver. It improved her health so much that it inspired me to find the money to start myself on milk thistle extract and I have had some noticeable health benefits too. (My liver values weren't even "out of range.") (e.g. I have a severe alcohol allergy and even if a tiny amount is in food I'd get violently ill. food poisoning ill, headaches, and my abdomen would be stiff for a day or two. Now being on the milk thistle, a tiny bit of alcohol in food only gives me mild discomfort.) I would highly recommend Denamarin not only for pets on the brink of death, but as part of a regular maintenance regiment for healthy pets. (Given as often as you can afford. Even if it is just once per week.) These do taste awful! My dog can't stand the taste of them. I can't hide them in anything. I have to push it down her throat. They did her so much good though that if I forget, she reminds me at that time every day. (Helps that I had lots of practice on a bigger dog years ago for another pill.) Though it says an hour between the pill & food, I've heard others say that it works better if it's two hours. I pushed it out to three hours when we can. I do give her a very tiny piece of treat in about two teaspoons of water in her bowl after pilling her to make sure it goes down all the way. I wanted to leave a positive review for this product much sooner, but kept forgetting. I wish I could leave something more articulate. I would give this product a five star review several times over. (This coming from a person who denounces most pharmaceuticals. My own Dr. has a hard time convincing me to take anything.)

It’s apparently the best product for liver issues for dogs. Not sure yet, as I have no outcome but many people I know used to cure liver issues.

This made such a difference in our dog that has liver enzyme issues. Not sure how it is possible, but she went 4 months Wii’s seizure while taking this. Before it was 2-3 weeks. She had more energy and basically was a different dog.

Very happy with my purchase

Lowered my dogs liver enzymes count substantially and will be using it for the rest of his life. Was recommended by my vet !

Arrived in a timely manner. My lab/doberman had copper storage disease, diagnosed at 3 years old. The vet gave her 2 weeks. Along with Zinc, homemade food, and distilled water, it seemed to have helped, and I was able to give her 3 more months.