Would this work for a 2019 21.5 4K iMac?

No. The tape strips work for a 27" monitor -- the length and placement of the notches won't suit a 21.5"

How difficult is it to remove this adhesive if the machine needs to be re-opened once sealed back up with these strips?

It is not hard to remove at all. One week after i used those strips, the screen fell off of my computer while i was sleeping. I bought a new screen but the logic board got damaged so now i have an 2020 i9 iMac that does not work. I would recommend the the 3M strips instead.

Is there any diagram how to use it? The strips look confusing and fragile. There must be a diagram provided either in this product page or in the box.

If you're talking about where the strips need to be installed I had wondered the same thing until I searched also on Ebay then it showed a diagram. #11 goes in the top left, #12 top right, #13 Right side and so forth all going clock wise in # order.

Anyone know if this will work on Late 2013 14,1 iMacs? 21.5”

14.1?it's fit for Late 2013 iMac 21.5" machine.

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LeFix Replacement LCD Panel Adhesive Tape Strip Sticker + Opening Wheel Tool Kit for iMac A1418 A1419 A1418 Tape Kit A1419 946-4470-18-19

Product ID: 278514656

📏Exact-fit adhesive strips for A1419 models

📦Professional protective packaging

🛠️Precision iMac opening tool included

Description

🖥️ Unlock flawless iMac repairs with precision and style!

ALL IN ONE REPAIR KIT - Includes specialized opening wheel tool for effortless, damage-free screen removal and replacement.
DURABLE RELIABLE ADHESION - High-quality tape strips that maintain strong hold under heat activation, preventing future display loosening.
SLEEK PROFESSIONAL PACKAGING - Robust box protects adhesive integrity, making your repair kit as polished as your workspace.
TAILORED FOR A 1419 EXCELLENCE - Specifically designed for iMac 27" A1419 (2012-2015), guaranteeing compatibility and optimal performance.
FLAWLESS I MAC SCREEN REASSEMBLY - Premium adhesive strips engineered for perfect, dust-free installation ensuring a seamless display fit every time.

LeFix Replacement LCD Panel Adhesive Tape Strip Sticker Kit is a premium, model-specific adhesive solution for iMac 27" A1419 (2012-2015). It includes six precision-cut adhesive strips and a professional-grade opening wheel tool, all housed in protective packaging. Designed for clean, dust-free installation, this kit ensures durable screen adhesion and effortless display removal, making it the go-to choice for professional-grade iMac repairs and upgrades.

Specifications

ASIN	B07GX8DFNB
Are Batteries Included	No
Best Sellers Rank	#57,362 in Computers ( See Top 100 in Computers ) #99 in Computer Repair Kits
Brand	LeFix
Color	A1419(27")
Customer Reviews	4.6 4.6 out of 5 stars (1,846)
Date First Available	2 December 2018
Item Weight	30 g
Item model number	946-4547
Manufacturer	LeFix
Package Dimensions	42 x 5.2 x 1.2 cm; 30 g
Standing screen display size	17 Inches

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