---
product_id: 3791305
title: "Nature Made SAM-e Complete 400 mg, SAM-e Supplement for Mood Support, Dietary Supplement, 36 Tablets, 36 Day Supply"
brand: "nature made"
price: "$265739"
currency: COP
in_stock: true
reviews_count: 8
category: "Nature Made"
url: https://www.desertcart.co/products/3791305-nature-made-sam-e-complete-400-mg-sam-e-supplement
store_origin: CO
region: Colombia
---

# Gluten-free 400 mg potency Mood support Nature Made SAM-e Complete 400 mg, SAM-e Supplement for Mood Support, Dietary Supplement, 36 Tablets, 36 Day Supply

**Brand:** nature made
**Price:** $265739
**Availability:** ✅ In Stock

## Summary

> 🌟 Unlock Your Best Self with Nature Made!

## Quick Answers

- **What is this?** Nature Made SAM-e Complete 400 mg, SAM-e Supplement for Mood Support, Dietary Supplement, 36 Tablets, 36 Day Supply by nature made
- **How much does it cost?** $265739 with free shipping
- **Is it available?** Yes, in stock and ready to ship
- **Where can I buy it?** [www.desertcart.co](https://www.desertcart.co/products/3791305-nature-made-sam-e-complete-400-mg-sam-e-supplement)

## Best For

- nature made enthusiasts

## Why This Product

- Trusted nature made brand quality
- Free international shipping included
- Worldwide delivery with tracking
- 15-day hassle-free returns

## Key Features

- • **Elevate Your Mood:** Harness the power of SAM-e for emotional well-being.
- • **Pharmacist Approved:** Trust the #1 recommended brand for vitamins.
- • **Daily Wellness Routine:** Just one tablet a day for a healthier you.
- • **Joint Comfort Champion:** Supports joint health with essential sulfur.
- • **Quality You Can Count On:** Sourced from high-quality, natural ingredients.

## Overview

Nature Made SAM-e Complete 400 mg is a dietary supplement designed to support mood and emotional well-being, while also promoting joint health. Each carton contains 36 tablets, providing a 36-day supply. This gluten-free supplement is made from high-quality ingredients and is free from artificial flavors and preservatives, making it a trusted choice for daily wellness.

## Description

Product Description Nature Made SAM-e Complete(1) 400 mg Tablets are dietary supplements that help support a healthy mood in as little as 7 to 14 days when taken daily. Sourced from high-quality ingredients, these SAMe 400mg mood support supplements are gluten free and contain no artificial flavors and no preservatives. SAM-e (S-adenosylmethionine) is a naturally occurring molecule produced by the body that can run low due to various factors such as a poor diet and aging. These Nature Made SAM-e Complete mood supplements also act as joint health supplements, providing a source of sulfur which is a critical component of joint tissue to help support joint comfort. These SAM-e supplements are a great choice for adults who are looking to replenish their SAM-e levels. Adults, start by taking one SAM e supplement tablet daily with water on an empty stomach. (1)Complete because studies have shown that SAM-e helps support a healthy mood & joint comfort. *Based on a survey of pharmacists who recommend branded vitamins and supplements. These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. Brand Story By Nature Made

Review: Very high quality SAM-e, possibly the best in the market. - I have an injury to my right hip joint. A small piece of bone is in my joint. There was a 50% chance that surgery would make it worse, so I didn't have a hip surgery. I heard someone praise SAM-e on Doctor Radio, so I bought the enterically coated brand that was mentioned along with some others. Nature Made SAM-e has stopped the pain. I take 2 of the tablets for best effectiveness. Studies have shown that joint comfort from SAM-e supplementation is best achieved at 600 to 1200 mgs. I don't use it for mood support which by the way would need a higher dose. I tried another brand that was on sale at desertcart, but after a month my hip pain was insufferable and had to take Aleve to do simple tasks. I started taking this brand of SAM-e again and in a few days the pain was gone so I didn't need Aleve.
Review: The Best SAM-e - Nature Made is the best SAM-e. Can never find it in Walgreens or Rite Aid anymore. Sucks because it was the only way it was affordable when it would be bogo. They don’t even sell the Walgreens or Rite Aid brands anymore I don’t get it. I bought naturemade religiously for over 20 years. I can’t afford it at this price but as long as the expiration date is like 2 years out and it’s fresh, they always made the best one. Enteric coated, empty stomach with B12, B6 & Folic acid. 1200-1600 mg a day for mood. 400-800 for joints and liver detoxification. Miracle supplement.

## Features

- Mood support supplement: contains one 36 count carton of Nature Made SAM-e Complete(1) 400 mg Tablets
- Nature Made SAM-e 400mg tablets offer a mood supplement that helps support a healthy mood and emotional wellbeing
- SAM e 400mg is also a joint health supplement, providing a source of sulfur to help support joint comfort
- Adults, start by taking one SAM e supplement tablet daily with water on an empty stomach
- Sourced from high-quality ingredients, this SAM-e supplement is gluten free and contains no artificial flavors and no preservatives
- #1 Pharmacist Recommended Vitamin & Supplement Brand*
- These statements have not been evaluated by the Food and Drug Administration; this product is not intended to diagnose, treat, cure, or prevent any disease

## Product Details

- **Brand:** Nature Made
- **Flavor:** Unflavored
- **Primary Supplement Type:** Vitamin
- **Unit Count:** 36 Count
- **Item Form:** Tablet
- **Item Weight:** 2.4 ounces
- **Item dimensions L x W x H:** 2.25 x 3.13 x 5.13 inches
- **Diet Type:** Vegetarian
- **Product Benefits:** Mood Support,Joint Support
- **Age Range (Description):** Adult

## Images

![Nature Made SAM-e Complete 400 mg, SAM-e Supplement for Mood Support, Dietary Supplement, 36 Tablets, 36 Day Supply - Image 1](https://m.media-amazon.com/images/I/71o3Z4cNaFL.jpg)

## Available Options

This product comes in different **Size** options.

## Questions & Answers

**Q: does this product have mannitol in it?**
A: Yes but it is ingredient #10 out if 14.

**Q: What's the difference between Sam-e and Sam-e complete?**
A: Nature Made calls theirs complete but if the active ingredient is S-adenosylmethionine , I don't think there is a difference. They used to call it Sam-e Mood something or other but now it's "complete". Not sure why. Sam-e refers to the abbreviation of S-adenosylmethionine only.

**Q: How long does it take before you feel the effects of taking sam-e? thanks**
A: You start feeling better within an hour

**Q: Are they butanedisulfonate form in enteric-coated tablets??**
A: Mine says S-adenosylmethionine enteric coated.  I can't find the chemical term anywhere on the box you asked about.

## Customer Reviews

### ⭐⭐⭐⭐⭐ Very high quality SAM-e, possibly the best in the market.
*by R***E on September 14, 2025*

I have an injury to my right hip joint. A small piece of bone is in my joint. There was a 50% chance that surgery would make it worse, so I didn't have a hip surgery. I heard someone praise SAM-e on Doctor Radio, so I bought the enterically coated brand that was mentioned along with some others. Nature Made SAM-e has stopped the pain. I take 2 of the tablets for best effectiveness. Studies have shown that joint comfort from SAM-e supplementation is best achieved at 600 to 1200 mgs. I don't use it for mood support which by the way would need a higher dose. I tried another brand that was on sale at Amazon, but after a month my hip pain was insufferable and had to take Aleve to do simple tasks. I started taking this brand of SAM-e again and in a few days the pain was gone so I didn't need Aleve.

### ⭐⭐⭐⭐⭐ The Best SAM-e
*by J***N on June 7, 2025*

Nature Made is the best SAM-e. Can never find it in Walgreens or Rite Aid anymore. Sucks because it was the only way it was affordable when it would be bogo. They don’t even sell the Walgreens or Rite Aid brands anymore I don’t get it. I bought naturemade religiously for over 20 years. I can’t afford it at this price but as long as the expiration date is like 2 years out and it’s fresh, they always made the best one. Enteric coated, empty stomach with B12, B6 & Folic acid. 1200-1600 mg a day for mood. 400-800 for joints and liver detoxification. Miracle supplement.

### ⭐⭐⭐⭐⭐ Good effects, but pills are just too difficult to swallow for some people
*by S***R on September 11, 2025*

The effects are noticeable and positive. I accidentally bought this version and it was a good mistake because the pills are round and smaller (not small but smaller), making for easier swallowing compared to the lozenge shaped versions of SAM-e we used. However, the person taking it has difficulty swallowing pills so instead of buying this again we are trying a dissolvable brand of SAM-e. Would rather stick with Nature Made, but not until they do a melt one. If I could I'd give it 4.5 stars due to pill size.

## Frequently Bought Together

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*Product available on Desertcart Colombia*
*Store origin: CO*
*Last updated: 2026-01-22*