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Description

  • GeneName: ATF1; TREB36; EWS-ATF1; FUS/ATF-1; cAMP-dependent transcription factor ATF-1.
  • SynName: Activating Transcription Factor 1; TREB36; EWS-ATF1; FUS/ATF-1.
  • Homo sapiens activating transcription factor 1 (ATF1), mRNA.
  • Cyclic AMP-dependent transcription factor ATF-1; cyclic AMP-dependent transcription factor ATF-1.
  • cAMP-dependent transcription factor ATF-1; activating transcription factor 1.
  • Source: Sf9 insect cells; *Tested: Kinase Assay, Western Blot (WB).
  • Type: Recombinant Fusion Protein; *Species: Human; *Tag Information: GST tag.
  • Expression System: Sf9 insect cells using baculovirus.
  • Source Note: Recombinant full-length human ATF1 was expressed by baculovirus in Sf9 insect cells.
  • FREE-8GB-USBDrive for this item. Item is for research use. NOT for diagnostic/therapeutic procedure..
  • Imported from USA.
*Form: 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.; *Storage: Store product at -70 degree C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.; *Accession#: NP_005162.1; NM_005171; P18846; *Description: Recombinant full-length human ATF1 was expressed by baculovirus in Sf9 insect cells using a N-terminal GST tag.Scientific Background: ATF1 is a class of transcription factor that stimulates gene expression of several cell growth-related genes through protein kinase A-related cAMP response elements. ATF1 can physically associate with BRCA1 in vitro, in yeast, and in human cells and BRCA1 is implicated in the transcriptional activation of ATF1 target genes, some of which are involved in the transcriptional response to DNA damage (1). Mitogen- and stress-activated protein kinase 1 (MSK1) and MSK2 play a role in the stress-induced phosphorylation of ATF1 in primary embryonic fibroblasts. However, mitogen-induced phosphorylation of ATF1 is greatly reduced (2).; *NCBI Summary: This gene encodes an activating transcription factor, which belongs to the ATF subfamily and bZIP (basic-region leucine zipper) family. It influences cellular physiologic processes by regulating the expression of downstream target genes, which are related to growth, survival, and other cellular activities. This protein is phosphorylated at serine 63 in its kinase-inducible domain by serine/threonine kinases, cAMP-dependent protein kinase A, calmodulin-dependent protein kinase I/II, mitogen- and stress-activated protein kinase and cyclin-dependent kinase 3 (cdk-3). Its phosphorylation enhances its transactivation and transcriptional activities, and enhances cell transformation. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chi...
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ATF1 recombinant protein (Recombinant Protein)

Quantity
1

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